Study of the Survival of Recombinant Human Neuregulin-1β in Chronic Heart Failure (CHF) Patients

Inclusion Criteria: 1. Age between 18 and 80, both sex. 2. Left ventricular ejection fraction (LVEF)≤40% (ECHO). 3. NYNA functional class III\~Ⅳ. 4. Clinical symptom is steadily in the latest 1 week (no fluid retension, no weight gain). 5. Capable of signing the informed consent form. Exclusion Criteria: 1. Patients with acute pulmonary edema or acute hemodynamic disorder. 2. Patients with right heart failure caused by pulmonary disease. 3. Patients diagnosed with pericardial effusion or pleural effusion. 4. Patients with myocardial infarction during the preceding 3 months. 5. Patients with constrictive pericarditis, significant valvular pathological change or congenital heart diseases, severe pulmonary artery hypertension. 6. Unstable angina pectoris. 7. Cardiac surgery or cerebrovascular accident within recent six months. 8. Preparing for heart transplantation. 9. Serious ventricular arrhythmia (multi-morphological premature ventricular contraction, frequent paroxysmal ventricular tachycardia). 10. Serious hepatic or renal dysfunction caused by organic pathological changes (Cr\>3.0mg/dl, AST or ALT 10 times above the normal upper limit). 11. Serum potassium \<3.2 mmol/L or \>5.5 mmol/L. 12. Systolic blood pressure \<90mmHg or \>160mmHg. 13. Pregnant or plan to pregnant. 14. Patients who participated in any clinical trial in the recent three months. 15. Subject with a life expectancy less than 3 months as assessed by the investigator. 16. Serious nervous system diseases (Alzheimer's disease, advanced Parkinsonism). 17. History of any malignancy or suffering from cancer,or biopsy proven pre-malignant condition (eg DICS or cervical atypia). 18. Evidence (physical examination,CXR,ECHO or other tests) shows some active malignancy or adenoidal hypertrophy or neoplasm has effect on heart function or endocrine system, eg pheochromocytoma or hyperthyroidism. 19. Judging by the investigator, the patients could not complete the study or adhere to the study requirements (due to the management reasons or others).