Pantoprazole Magnesium 40 mg Versus Esomeprazole 40 mg in Patients With Erosive Gastroesophageal Reflux Disease

Inclusion Criteria: * Voluntary participation in the study with signature on Informed Consent Form (ICF) prior to specific protocol procedures * Patients of any race * On outpatient treatment * History of frequent symptom crises related to GERD within the last 3 months (at least a frequency of twice a week, for about four to eight weeks) * Diagnosis of erosive esophagitis (grade A to D, according to Los Angeles Classification) * In good health condition, except GERD symptoms * Able to follow the protocol directions and to complete daily the questionnaire ReQuest™ throughout the study Exclusion Criteria: * Gastrointestinal disorder, even when related to chlorhydropeptic disorders: Barret's esophagus, peptic ulcer, Zollinger-Ellison syndrome and pyloric stenosis * Previous history of surgery to reduce acid secretion, or other upper gastrointestinal tract surgeries (excepting polypectomy and cholecystectomy) * At initial endoscopy presenting complicated disorders due to erosive esophagitis: obstructive esophageal stenoses, Schatzki ring, esophageal diverticulum, esophageal varices, achalasia and hiatal hernia * Pregnant women or during nursing period * Proton Pump Inhibitors (PPIs) within the last 10 days prior to start of the study * Triple therapy based on PPIs to eradicate H. pylori within the last 28 days prior to start of the study * H2-blockers, sucralfate and prokinetics within the last 7 days prior to start of the study * Systemic glucocorticoids and/or nonsteroidal anti-inflammatory drugs (including COX-2 inhibitors) for more than 3 consecutive days a week, within the last 28 days prior to start of study, with exception of regular intake of acetyl salicylic acid in dosages of up to 163 mg/day.