Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

University Medical Center Nijmegen20 enrolled

Overview

The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Weaning Respiratory Muscle Function

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 year * mechanical ventilation for at least 3 days * the treating physician judges the patient to be ready to be weaned from the ventilator * informed consent Exclusion Criteria: * pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases. * upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia) * recent (\< 1 month) nasal bleeding * phrenic nerve lesions

Locations (1)

Radboud University Nijmegen Medical Center

Nijmegen, Gelderland, Netherlands

RECRUITING

Outcomes

Primary Outcomes

Fatiguability of the diaphragm

Time frame: Multiple measurements within 24 hours after start of weaning trial

Central Contacts

Leo Heunks, MD, PhD

CONTACT

+31 24 3617273 L.Heunks@ic.umcn.nl

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.