Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of Ultra Low Doses of Dapagliflozin in Healthy Subjects

Inclusion Criteria: * Healthy men and women * WOCBP who are using acceptable method of contraception * Women who are not nursing Exclusion Criteria: * History of GI disease * Any GI surgery that could impact study drug absorption * Glucosuria at screening or Day -2 * Abnormal liver function tests (ALT, AST or total bilirubin \> 10% above ULN) * History of current or recurrent UTI * History of Diabetes Mellitus * History of chronic or recurrent vulvovaginal mycotic infections * Estimated creatinine clearance (ClCr) \< 80 mL/min using Cockroft-Gault formula * History of allergy to SGLT2 inhibitors or related compounds