Paclitaxel and Irinotecan in Advanced Gastric Cancer

Inclusion Criteria: * Age 18 - 70 years * A patient who is able to walk and should have ECOG performance status of 0-1. * Histologically confirmed adenocarcinoma of the stomach * Unresectable locally advanced or initially metastatic or recurrent after curative resection * Prior one regimen chemotherapy including fluoropyrimidine and platinum. (FP, XP, TS-1+cisplatin, FOLFOX) * A patient with at least one measurable primary lesion of which the diameter is confirmed to be 10mm in Spiral CT or multidetector CT (MD CT), or 20 mm or longer in conventional CT (it should be used by a consistent method during the study period). * A patient with the willingness to comply with the study protocol during the study period and capable of complying with it. * A patient who signed the informed consent prior to the participation of the study and who understands that he/she has a right to withdrawal from participation in the study at any time without any disadvantages. Exclusion Criteria: * A patient with no measurable disease * A patient with previous chemotherapy without containing fluoropyrimidine or platinum. * A patient with UGT1A1\*28 allele ((TA)7/7 homozygosity) * A patient with previous active or passive immunotherapy. * A patient with intestinal obstruction or impending obstruction, recent active upper GI bleeding * A pregnant or lactating patient * A patient of childbearing potential without being tested for pregnancy at baseline or with being tested for positive. (A postmenopausal woman with the amenorrhea period of at least 12 months or longer is considered to have non-childbearing potential.) * A man or woman of childbearing potential who has no willingness to use a contraceptive measure during the study. * A patient with history of another malignant disease within past 5 years, except curatively treated basal cell carcinoma of the skin and cervical carcinoma in situ are excluded. * A patient with history of uncontrolled seizures, central nervous system disorder or psychiatric disorders that are considered clinically significant by the investigator that would prohibit the understanding of informed consent or that may be considered to interfere with the compliance of the administration of the study medications. * A patient with clinically significant (i.e. active) heart disease (e.g. congestive heart failure, symptomatic coronary artery diseases, cardiac arrhythmias, etc) or myocardial infarction within past 12 months. * A patient with interstitial pneumonia or diffused symptomatic fibrosis of the lungs. * A patient with peripheral neuropathy of Grade 1 by NCI CTC, caused by other factors (e.g. alcohol, diabetes, etc). If the absence of deep tendon reflexes (DTRs) is the only neurologic disorder, this condition does not apply to the exclusion criteria. * Organ allogenic transplantation requiring immunosuppressive therapy. * A patient who developed uncontrolled serious infection or other uncontrolled serious concomitant diseases. * A patient with moderate or severe renal insufficiency or serum creatinine \> 1.5 X upper limit of normal\]. * Adequate organ function * A patient with hypersensitivity. * A patient who has received major surgery within 4 weeks prior to the initiation of the study or a patient who is not completely recovered from impact of the major surgery. * A patient who has participated in a clinical trial with other medications or therapy within 4 weeks prior to the initiation of the study.