Cancer is one of the leading health issues in this country and worldwide. Angiogenesis is an essential process for tumoral growth and metastasis. This process is dependent on the balance between angiogenic factors and antiangiogenic factors. Muscle wasting has been associated with myostatin overexpression in cancer. Exercise training can depress tumor growth and suppress myostatin expression, and enhance skeletal muscle angiogenesis in healthy people and some animal studies. The purpose of this study is mainly to investigate the effects of exercise training on 1. circulating VEGF-A 2. muscle growth and function 3. Myostatin
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Subjects in exercise group will undergo individualized high aerobic interval training on treadmill for 30 minutes under the supervision of an experienced physical therapist 3 times a week and home exercise twice a week with accelerometer.
Subjects in control group will not undergo individualized high aerobic interval training on treadmill. They will receive usual care as normally does in hospital.
National Taiwan University Hospital
Taipei, Taiwan
Exercise capacity
Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS
Time frame: 8 weeks after the start of the intervention
Imaging of muscle
Measured by MRS
Time frame: 8 weeks and 16 weeks after the start of the intervention
Analysis of venous blood sample
Analysis of circulating VEGF-A and myostatin
Time frame: 8 weeks andd 16 weeks after the start of the intervention
Quality of life
Measured by questionnaire
Time frame: baseline, 8 weeks, 16 weeks
Exercise capacity
Maximal oxygen consumption with Vmax229 Vastus lateral muscle oxygenation with NIRS
Time frame: 16 weeks after the start of the intervention
Muscle function
Isokinetic muscle strength and endurance with Biodex
Time frame: 8 weeks and 16 weeks after the start of the intervention
Physical activity
Measured with 7-day recall questionnaire
Time frame: 8 weeks andd 16 weeks after the start of the intervention
Dietary intake
Measured with 24-hour recall questionnaire
Time frame: 8 weeks andd 16 weeks after the start of the intervention
Body composition
Body mass index calculated with body weight and height % body fat abd free-fat mass with BIA
Time frame: 8 weeks andd 16 weeks after the start of the intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.