Investigators hypothesized home-based exercise intervention was beneficial to those who have had diabetic risk factor for type 2 diabetes mellitus
This randomized clinical trial was designed to investigate whether a home-based exercise could improve adiponectin levels, exercise behavior and metabolic risk factors (insulin resistance, metabolic components and physical fitness) in subjects with at least a diabetic risk factor for type 2 diabetes mellitus. Participants were randomly allocated to either a control group or a home-based exercise group. All participants were evaluated for outcome measures at baseline, and at 3-month 6-month and 9-month follow-up after engaging in the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
DOUBLE
Enrollment
216
1. An interview with a physiotherapist 2. An exercise video specially designed by this study including warm-up, aerobic, cool-down and stretching exercises, and/or a simple exerciser to use at home 3. An individualized home-based exercise program based on the Health Belief Model and Transtheoretical Model 4. The daily record to check their body weight, exercise mode and duration 5. Proper diet, caloric intake calculation, metabolic risk factors and prevention of diabetes were taught and a guide book was provided that included all the above mentioned details 6. Telephone reminders of healthy lifestyle including the ways of overcoming barriers of regular exercise every 1 to 2 weeks for 3 months, 1-2 calls a month afterwards and no calls for the last month on a tapered off schedule
1. Oral instruction and written general education information about weight control, proper diet and regular exercise in a one-page education brochure that was similar to the way used in the outpatient clinic 2. Telephone reminders of healthy lifestyle every 1 to 2 weeks for 3 months, 1-2 calls a month afterwards and no calls for the last month on a tapered off schedule 3. Without individualized exercise program and interview with a physiotherapist
National Taiwan University Hospital
Taipei, Taiwan
Plasma adiponectin level in μg/ml
Fasting blood samples were centrifuged to obtain plasma and then immediately stored at -20℃. Plasma adiponectin levels were then determined through enzyme-linked immunoassay (ELISA).
Time frame: Nine months after the start of the intervention
Exercise behavior
1. Exercise self-efficacy: Measured by exercise self-efficacy questionnaire in score 2. Physical activity: Meausred by 7-day recall questionnaire in kcal/kg/day
Time frame: Nine months after the start of the intervention
Insulin resistance
plasma inulin level (μU/ml) meausred by AxSYM with HOMA-IR was caculated
Time frame: Three, 6 and 9 months after the start of the intervention
Metabolic components
1. Waist circumference (cm) 2. Fasting blood samples were centrifuged to obtain plasma for plasma triglycerides (TG) and high-density lipoprotein (HDL) levels in mg/dl 3. Plasma fasting glucose (FG) levels were measured in mg/dl by using the glucose oxidase membrane/hydrogen peroxide electrode method with the Antsense II analyzer (Bayer-Sankyo Co., Tokyo, Japan) 4. Systolic blood pressure (SBP) and dystolic blood pressure (DBP) in mmHg
Time frame: Three, 6 and 9 months after the start of the intervention
Physical fitness
1. Body composition (kg/m\^2): Body mass index that was weight in kilograms divided by the square of height in meter 2. Flexibility (cm): Meausred by sit-and-reach test 3. Grip strength (Nm): Measured by Jamar handheld dynameter 4. Muscle endurance (times/min): Measured by sit-up test 5. Cardiopulmonary fitness (3-minute step test)
Time frame: Three, 6 and 9 months after the start of the intervention
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Dietary intake
Measured by 24-hour recall guestionnaire in kcal/kg/day
Time frame: Three, 6 and 9 months after the start of the intervention
Plasma adiponectin level in μg/ml
Fasting blood samples were centrifuged to obtain plasma and then immediately stored at -20℃. Plasma adiponectin levels were then determined through enzyme-linked immunoassay (ELISA)
Time frame: Three and 6 months after the start of the intervention
Exercise behavior
1. Exercise self-efficacy: Measured by exercise self-efficacy questionnaire in score 2. Physical activity: Meausred by 7-day recall questionnaire in kcal/kg/day
Time frame: Three and 6 months after the start of the intervention