The investigators propose a pilot study to test the novel hypothesis that Exenatide treatment in patients with type 2 diabetes results in improved sleep duration and quality and to explore the relationship between improvements in sleep and measures of metabolic and circadian function. This project would be the first to probe the relationship between incretin hormone regulation, duration and intensity of sleep, glucose tolerance and circadian dysfunction in diabetic patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
18
The University of Chicago
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Non-REM Slow Wave Sleep
Total minutes of non-REM sleep was measured
Time frame: baseline and after 6 weeks of treatment
Total Amount of Slow Wave Activity
Total amount of slow wave activity during sleep derived from laboratory polysomnogram was measured
Time frame: baseline and after 6 weeks of treatment
Sleep Efficiency During Polysomnographic Recording
Sleep efficiency will be calculated as total sleep time over total recording time.
Time frame: baseline and after 6 weeks of treatment
Minutes of Wake After Sleep Onset During Sleep Recording
total amount of time spent awake after sleep onset and before morning awakening will be calculated
Time frame: baseline and after 6 weeks of treatment
Severity of Obstructive Sleep Apnea
The apnea-hypopnea index (AHI) will be calculated from polysomnographic recordings. The minimum score for AHI is 0 (zero), corresponding to total absence of apnea or hypopnea. There is no theoretical maximum score although scores above 100 are very rarely observed. The lower the AHI value, the better. Higher AHI values correspond to greater severity of sleep apnea, a worse outcome. There are no subscales. We use continuous AHI values to measure severity of obstructive sleep apnea.
Time frame: baseline and after 6 weeks of treatment
Mean 24-h Blood Glucose Levels
Mean plasma levels of glucose will be calculated from samples collected across the 24-h cycle.
Time frame: baseline and after 6 weeks of treatment
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