Biomarkers in Patients With Acute Myeloid Leukemia

Children's Oncology Group18 enrolled

Overview

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in patients with acute myeloid leukemia.

OBJECTIVES: * To determine whether clonally expanded somatic mitochondrial DNA mutations are associated with acute myeloid leukemia. OUTLINE: Genomic DNA from blood samples obtained at diagnosis, remission, and relapse are analyzed for mitochondrial DNA mutations via PCR.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

DNA analysisGENETIC

mutation analysisGENETIC

polymerase chain reactionGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Available blood samples from diagnosis, remission, and relapse PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Association between clonally expanded somatic mitochondrial DNA mutations and acute myeloid leukemia

Data from ClinicalTrials.gov

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