Biomarkers in Young Patients With Acute Myeloid Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.

OBJECTIVES: * Determine the frequency of ligand-independent phosphorylation of Stat3 in a small cohort of samples from pediatric patients with acute myeloid leukemia including, but not limited to, samples known to express mutated c-kit. * Measure the level of Stat3 phosphorylation in these samples after stimulation of three key cytokine receptors expressed on hematopoietic cells IL-6R, G-CSFR, and c-kit. OUTLINE: Cryopreserved samples are analyzed for levels of various components of the Stat3 pathway via western blotting.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

western blottingGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALLMax age: 21 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * One of the following karyotypes: * t(8;21) and WT c-kit * t(8;21) and mutant c-kit * Normal karyotype PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Correlations between levels of pY-Stat3 and levels of upstream cytokine receptors

Association of constitutive and/or increased pY-Stat3 and c-kit genotype

Data from ClinicalTrials.gov

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