This study will evaluate the test-retest repeatability of lactate and other metabolites measured by single voxel magnetic resonance spectroscopy (MRS) and multi-voxel magnetic resonance spectroscopic imaging experiments (MRSI) in tumor tissue in patients radiographically diagnosed with glioma. These measurements will test whether the concentration of lactate in tumor will be higher than the concentration of lactate in normal tissue of the same patient.
Study Type
OBSERVATIONAL
Enrollment
8
The test-retest repeatability of lactate and other metabolites when measured by multi-voxel MRSI in tumor tissue
Time frame: 90 minutes
The test-retest repeatability of lactate and other metabolites when measured by single voxel MRS
Time frame: 90 minutes
The geometric mean fold rise (GMFR) in the concentrations of lactate and each of the other metabolites for tumor/normal tissue
Time frame: 90 minutes
The test-retest repeatability of lactate and other metabolites when measured by multi-voxel MRSI in normal tissue
Time frame: 90 minutes
True geometric mean ratio (GMR) of the MRSI/SV MRS concentration values
Time frame: 90 minutes
The mean levels of each of the metabolites will be summarized by tumor grade and type
Time frame: 90 minutes
The correlation between in vivo (measured by MRSI) and in vitro levels of lactate and other metabolites in tumors
Time frame: 90 minutes
The within day and between day standard deviations for each metabolite
Time frame: 90 minutes
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