Prophylaxis of Hepatitis B Virus Recurrence After Liver Transplantation

Inclusion Criteria: 1. patients into the transplant waiting list with HBV-related liver disease. 2. HBsAg-positive. 3. serum HBV-DNA negative. 4. no HCV, HDV and HIV co-infection. 5. without renal dysfunction. 6. No lamivudine, adefovir and entecavir drug allergy history. 7. no HBV-YMDD mutation for patients who have a long-term use of lamivudine. Exclusion Criteria: 1. patients with HBV-related hepatocellular carcinoma beyond Milan criteria. 2. HBsAg-negative. 3. serum HBV-DNA positive. 4. HCV, HDV and HIV co-infection. 5. patients with severe renal dysfunction or failure. 6. lamivudine, adefovir and entecavir drug allergy history. 7. HBV-YMDD mutation for patients who have a long-term use of lamivudine.