Blood and Tumor Tissue Samples From Young Patients With Acute Myeloid Leukemia

Children's Oncology Group52 enrolled

Overview

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.

OBJECTIVES: * To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML). * To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients. OUTLINE: This is a multicenter study. Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

gene expression analysisGENETIC

western blottingGENETIC

flow cytometryOTHER

laboratory biomarker analysisOTHER

Eligibility

Sex: ALLMax age: 17 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Children Oncology Group (COG) patient samples PATIENT CHARACTERISTICS: * Available clinical data PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Expression of Mer and Axl

Association of abnormal expression of Mer and Axl with induction failure or relapse

Data from ClinicalTrials.gov

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