The purpose of this study is to assess the affect that PF-00232798 has on QT interval. A prolonged QT interval is a risk factor for arrhythmias.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
44
600 mg oral solution once daily x 7 days
300 mg oral solution once daily x 7 days
Oral solution once daily x 7 days
Pfizer Investigational Site
Singapore, Singapore
QTc, using Fridericia's correction method (QTcF) at each time point of PF-00232798 and placebo on Day 7.
Time frame: 7 days
QTcF, or any other appropriate correction method at each postdose time point of moxifloxacin on Day 7
Time frame: 7 days
QTcB or any other appropriate correction method at each postdose time point of PF-00232798 and placebo on Day 7
Time frame: 7 days
Pharmacokinetic endpoints for PF-00232798 (Tmax, Cmax, Cτ, and AUClast)
Time frame: 7 days
Safety and toleration assessed by spontaneous reporting of adverse events, vital signs, 12-lead ECG and laboratory safety assessments
Time frame: 7 days
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400 mg tablet single dose