The purpose of this study is to determine tranexamic acid plasma levels in children undergoing cardiac surgery at risk of bleeding and to compare two dosing regimens.
Tranexamic acid (TXA) is administered intravenously to prevent bleeding associated with cardiac surgery and by pass in adult and children. The pharmacokinetic of this product is unknown in the pediatric population. Only a few studies report a clinical efficacy with different dosages. The purpose of this study is to determine the plasma level of TXA using two different administrations methods: continuous versus intermittent. The second objective is to determine whether fibrinolysis decreased. The population consists in children weighting 10 to 30 Kilos, undergoing cardiac surgery and at high risk of bleeding.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
18
Comparison of two dosage regimen of Tranexamic Acid
Centre Chirurgical Marie Lannelongue
Le Plessis-Robinson, France
Preoperative plasma tranexamic acid concentration is measured using high performance liquid chromatography
Time frame: Blood samples are collected during the operative period within 24 hours
preoperative plasma tranexamic acid concentration is measured using high performance liquid chromatography
Time frame: blood samples collected during the operative period within the first 24 hours
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