Anticoagulation in Stent Intervention

Inclusion Criteria: * Patients of both sexes older than 18 years. * Patients with permanent atrial fibrillation, persistent or paroxysmal (at least one episode), documented electrocardiographically and receiving oral anticoagulation. Patients with acute coronary syndrome or stable angina who are undergoing PCI-S. * Patients who have previously given their informed consent to participation in the study. Exclusion Criteria: * Patients who can not be followed by the research team during the 12 months provided for monitoring. * Patients with renal failure or serum creatinine above 2 mg • dL-1, neurological deficits, active ulcer or epigastric pain. * Patients who continue regular treatment with NSAIDs or other analgesics or corticosteroids. * Patients undergoing reoperation. * Patients who during the study period, should receive, according to medical criteria, other adjuvant drug treatment than that specified in this protocol. * Pregnant women. * Use of investigational agents or not registered within 30 days of entry into the study. * Patients with a history of allergy to study drugs or excipients. * Patients with severe valve disease. * Patients with CHADS\> 2. * Patients who can not use the study drug orally.