Outcomes in MEasurement-Based Treatment

Inclusion Criteria: * Age ≥18 years old * Diagnosis of major depressive disorder * Prescribed a new prescription for an antidepressant medication on the date of study enrollment and currently taking the medication 'New' is defined as no antidepressant use in the previous 120 days * Primary depression management is performed by the primary care provider * Capable of self-management (i.e., taking medications and independently responding to follow-up contacts) * Able to provide informed consent to participate * Sufficient ability as judged by the physician to read, understand and complete survey instruments written in English and phone interviews spoken in English Exclusion Criteria: * History psychotic disorder or bipolar disorder * Diagnosis of current postpartum depression * Diagnosis of bereavement less than 8 weeks duration * Currently pregnant * History of suicide attempts or current suicide plan * Need for psychiatric hospitalization at enrollment visit * History of adjunctive treatments including electroconvulsive treatment (ECT), vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), magnetic seizure therapy (MST), or deep brain stimulation (DBS)