Purpose: The overall objective of this study is to learn more about the disease chronic pancreatitis and thus contribute to better treatments. The investigators will gain this by studying the effects of vitamin D in the body immune system and bones. The investigators will also study the uptake of vitamin D through the intestine compared with the amount of vitamin D obtained through exposure to UVB rays. The investigators have set a series of questions which the investigators want to answer with this experiment: Do patients with chronic pancreatitis have reduced absorption of vitamin D from the gut? * Have the two treatment methods with vitamin D, UV radiation and tablets, the same success rate? * Does the distribution of the white blood cells change when the vitamin D level increases and does it depend on whether the patient have UVB radiation or tablet with vitamin D? * Will patients require reduced amounts of painkillers when vitamin D level increases? * Does vitamin D have influence on blood sugar and thus the risk of diabetes or worsening of this? * Could vitamin D affect the blood content of inflammation markers? * Does the patient feel better when he takes vitamin D? * Does bone strength increase when the patients receive grants of vitamin D?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
27
400 mg calcium two times daily. From week 0 to 10 and week 14 to 52.
38 micrograms daily. Week 0-10.
Ultraviolet radiation type B administered in a tanning bed. One time weekly.
Light from a tanning bed but a UV-filter stops all ultraviolet radiation. One time weekly.
38 micrograms daily. From week 14 to 52.
Hvidovre Hospital
Hvidovre, Denmark
25-hydroxyvitamin D
Time frame: Week 0, 2, 6, 10, 14, 20, 30, 40, 52
T-lymphocytes subsets.
Subsets of T-lymphocytes including regulatory T-lymphocytes (Tregs) and CD4+ and CD8+ lymphocytes.
Time frame: Week 0, 10
Ionized calcium
Time frame: week 0, 2, 6, 10, 14, 20, 30, 40, 52
Parathyroid hormone
To evaluate bone-metabolism.
Time frame: Week 0, 2, 6, 10, 14, 20, 30, 40, 52
QoL score
Evaluation of self-reported health using two questionnaires: QLQ-C30 QLQ-Pan(30)
Time frame: Week 0, 10
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