Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet

Inclusion Criteria:a. 1. Postmenopausal female or male over 30 years of age at the time the consent form is signed. 2. Subject has a BMI between 27 and 35 kg/m2 3. Subject is in good health based on history, physical examination, and basic laboratory studies. 4. Consumes less than one alcoholic beverage per day 5. Is a non-smoker for at least three months 6. Willing to follow a Very Low Calorie Diet of 800 calories per day using meal replacements 7. Ethical: Subject must sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or randomization. A subject will be excluded for any condition that might compromise the ability to give truly informed consent for participation in the study. Exclusion Criteria: 1. Any subject with known allergy to chili peppers by history. 2. Any subject with type 2 diabetes or glucose intolerance 3. Consumes more than one alcoholic beverage per day 4. Any subject participating in regular vigorous exercises other than ordinary daily walks or who is unwilling to maintain their usual level of exercise during the study. 5. Any subject with a diagnosed eating disorder or who is addicted to any medications. 6. Any subject currently taking antidepressants or weight loss medication. 7. Any subjects with a history of gastrointestinal surgery, uncontrolled hypertension, or other serious medical condition, such as chronic hepatitis or renal disease, bleeding disorder, congestive heart disease, chronic diarrhea disorders, myocardial infarction, coronary artery bypass graft, angioplasty within 6 months prior to screening, current diagnosis of uncontrolled hypertension (defined as BP \>160mmHg, diastolic BP\>95mmHg), active or chronic gastrointestinal disorders, bulimia, anorexia, laxative abuse, or endocrine diseases (except thyroid disease requiring medication) as indicated by medical history or routine physical examination. 8. Major surgery within 12 weeks prior to subject randomization and/or screening, especially cardiac surgery 9. Is currently a smoker who has a therapeutic plan to quit smoking anytime during the study period; or if not a current smoker, has quit smoking within the past 3 months. 10. Known HIV positive. 11. Clinical evidence of current malignancy with the exception of basal cell or squamous cell carcinoma of the skin and cervical intraepithelial neoplasia. 12. Currently receiving systemic chemotherapy and/or radiotherapy. 13. Active bleeding. 14. Subject has any disorder including illiteracy or visual impairment that compromises the ability of the subject to give written informed consent and/or to comply with study procedures. 15. In the opinion of the study investigator has a risk of non-compliance with study procedures, or cannot read, understand or complete study related materials.