Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)

Inclusion Criteria: * age greater than 18 years, if female, must be menopausal or had hysterectomy * resident and citizen of the United States * history of a chronic onset of a progressive motor weakness * able to comply with protocol requirements * can provide written consent Exclusion Criteria: * does not have renal disease (Creatine \> 2.0) * does not have active systemic disease * does not have any clinically significant abnormalities on prestudy laboratory evaluation * does not have any clinically significant medical condition (e.g.,within 6 months of baseline, had a myocardial infarct, angina pectoris, and/or congestive heart failure), that in the opinion of the investigator, would compromise the safety of the patient * does not have a history of cancer including melanoma with the exception of localized skin cancers (with no evidence of metastasis, significant invasion,or re-occurrence within 3 years of baseline). * has not used an investigational drug within 30 days of baseline visit * does not have a tracheostomy * does not have a Beck's Depression Inventory score \>16