Dose Response Effect of Probiotics for the Prevention of Antibiotic-associated Diarrhea in Chinese Adults

Changhai Hospital510 enrolled

Overview

The purpose of this study is to determine the dose response effect of probiotic capsules for the prevention of antibiotic-associated diarrhea (AAD).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

510

Conditions

Antibiotic-associated Diarrhea

Interventions

ProbioticDIETARY_SUPPLEMENT

L. acidophilus, L. paracasei, B. lactis; 2.5 billion cfu capsule once per day

ProbioticDIETARY_SUPPLEMENT

L. acidophilus, L. paracasei, B. lactis; 10 billion cfu capsule once per day

PlaceboOTHER

Placebo

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 30-70 years * initiating antibiotic therapy * informed consent Exclusion Criteria: * current diarrhea * life threatening illness * habitual probiotic use

Locations (1)

Changhai Hospital

Shanghai, China

Outcomes

Primary Outcomes

Incidence of antibiotic-associated diarrhea

Time frame: 5 weeks after antibiotic discontinuation

Data from ClinicalTrials.gov

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