The standard approach to sedation in endoscopic retrograde cholangiopancreatography (ERCP) involves the use of benzodiazepines and opiates to achieve a moderate depth of sedation. There is data to suggest supplementing this regimen with gabapentin may lead to reduced pain, higher patient satisfaction and lower opiate requirements. The investigators are conducting a clinical trial to study this hypothesis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
56
gabapentin 900mg PO x 1 dose, 1 hour prior to the procedure
Combination opiate and benzodiazepine will be administered to achieve moderate sedation. This is the standard of care.
University Hospital, Indiana University Purdue University Indianapolis
Indianapolis, Indiana, United States
Dosing Requirements
Assess the effect of a single 900mg dose of gabapentin pre- ERCP on intra and post procedure narcotic/sedative requirements.
Time frame: At time of discharge post-procedure
Number of Participants With Sedation-Related Adverse Events
Sedation-related adverse events
Time frame: At time of discharge post-procedure
Median Pain Score at Time of Discharge
Assess the effect of a single 900mg dose of gabapentin on pain at time of discharge, measured by a visual analog scale ranging from 0 (worst pain) to 100 (no pain).
Time frame: At time of discharge post-procedure
Median Anxiety Score at Time of Discharge
Assess the effect of a single 900mg dose of gabapentin on anxiety at time of discharge, measured by a visual analog scale ranging from 0 (worst anxiety) to 100 (no anxiety).
Time frame: At time of discharge post-procedure
Median Nausea Score at Time of Discharge
Assess the effect of a single 900mg dose of gabapentin on nausea at time of discharge, measured by a visual analog scale ranging from 0 (worst nausea) to 100 (no nausea).
Time frame: At time of discharge post-procedure
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