Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair

Medical University of Vienna27 enrolled

Overview

Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left ventricular hypertrophy . Methods: 25 patients will be included in this double-blind randomized placebo-controlled study. Glutamate was administered intravenously immediately after aortic cross-clamp release. The patients receive either a low dose of 30mg kg-1 h-1 (LG-group) or high dose of 60 mg kg-1 h-1 (HG-group) or placebo (P-group) at a rate of 3.3ml kg-1h-1 for 2h. Transesophageal echocardiography (TEE) is used to measure diastolic and systolic ventricular function before sternotomy (T0), and 2h (T2), 3h (T3) and 6h (T4) after release of cross clamp. Additionally routine hemodynamic parameters are measured intraoperatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Enrollment

Conditions

Hypertrophy, Left Ventricular Aortic Stenosis Myocardial Ischemia Cardiopulmonary Bypass

Eligibility

Sex: ALLMin age: 19 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * severe aortic stenosis * left ventricular hypertrophy of more than 10mm IVS thickness * normal ejection fraction * SR Exclusion Criteria: * moderately or severely reduced systolic left ventricular function (ejection fraction \<30%) * atrial fibrillation or flutter * intolerance to glutamate.

Outcomes

Primary Outcomes

flow propagational velocity

Isovolumic relaxation time

E-velocity

A-velocity

E/A ratio

Secondary Outcomes

ejection fraction

cardiac output

mitral ring motion