WCC# 59 Hyperthermic Intraperitoneal Chemotherapy Utilizing Carboplatin in First Recurrence Ovarian Cancer

Inclusion Criteria: * Patients should have a histological diagnosis of primary ovarian, fallopian tube, or primary peritoneal carcinoma and have undergone chemotherapy according. * Initial attempted cytoreductive surgery must have been performed by gynecologic oncologist with strict adherence to GOG surgical manual. * End result of first surgery must have been optimal cytoreduction as defined as no residual tumor ≥ 1cm. * Patients should have clinical evidence of first recurrence. Two fold elevations in CA125 or measurable tumor on CT scan constitute adequate evidence of recurrent disease. * Patients with the following primary tumor epithelial cell types are eligible: serous adenocarcinoma, endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, adenocarcinoma (non-specific) NOS, mixed epithelial carcinoma. * Patients must have platin sensitive disease, defined as a recurrence occurring greater than 6 months from cessation of original treatment. * Patients must have a performance status of 0, 1, 2. * Patients must have adequate bone marrow function as defined by an absolute neutrophil count (ANC) ≥1500, platelet count ≥ 100,000, and a hemoglobin of greater than 10g/dl. * Patients must have adequate renal function as defined by serum creatinine ≤ 1.5 mg/dl. * Patients must have adequate hepatic function as defined by bilirubin ≤ 1.5 times normal levels, alkaline phosphatase and SGOT ≤ 3 times normal levels. * Patients who have signed an Institutional Review Board (IRB) approved informed consent. * Female patients 16-90 years of age. * Patients must be deemed medically able to undergo a secondary surgical procedure. Patient eligibility for systemic chemotherapy following HIPC: * Patients must have successfully completed HIPC within 6 weeks of first prescribed intravenous carboplatin and taxane cycle. * Patients must have a performance status of 0, 1, or 2. * Patients must have adequate bone marrow function as defined as an ANC ≥ 1500, platelet count ≥ 100,000, and a hemoglobin of greater than 10g/dl. * Patients must have adequate renal function as defined by serum creatinine ≤ 1.5 mg/dl. * Patients must have adequate hepatic function as defined by bilirubin ≤ 1.5 times normal levels, alkaline phosphatase and SGOT ≤ 3 times normal levels. * Patients who have signed an IRB approved informed consent. Exclusion Criteria: * Patients with known recurrent disease outside the abdominal cavity. * Patients with low malignant tumor at primary diagnosis as determined by pathologic review. * Patients with platin resistant disease as define as recurrence or progressive disease prior to 6 months from completion of primary therapy. * Patients with any evidence of another malignancy within the last 5 years with the exception of non-melanoma skin cancer. * Patients with evidence of concurrent septicemia, severe infection, renal failure, or acute hepatitis. * Patients with history of grade 3 or greater gastrointestinal bleeding. * Patients with a GOG performance score of 3 or 4. * Patients deemed medically unable to tolerate the HIPC procedure by care giving physician. * Patients with known allergy to platinum chemotherapy agents. * Patients with equal to or greater than grade 2 neuropathy.