A Pilot Study for Pharmacokinetic/Pharmacodynamic (PK/PD) Parameter of Allopurinol and Its Metabolite-oxypurinol After Once-daily Allopurinol in Chronic Kidney Disease Patient

Inclusion Criteria: * from 18yrs to 80yrs , man and women * the patient who are taking allopurinol * On screening, the patient shows that the level of protein/creatinine ratio is over 3.0 * On screening, the patient shows that MDRD GFR \>= 30 ml/min and \<= 60 ml/min * the patient sign on the concent form Exclusion Criteria: * the patient have experience to take medication that have an effect on renal function * the patient have experience to take cyclosporin within 3month * At least, the average level of two separate blood pressure ( 2min interval ) shows that SBP \<= 100 mmHg or \>=160 mmHg and DBP \<=60 mmHg \>=100 mmHg, or Heart rate \< 40 beats/min or \> 90 beats/min * uncontrolled hypertension * pregnancy or anticipate pregnancy with 6 month * hypersensitivity to allopurinol * acute hepatitis or the level of AST or ALT is over 2times of normal range or the level of bilirubin is over 2.0 mg/dL * serum albumin \< 3.5 mg/dL or \> 5mg/dL * urinary retension, prostatic hyperplasia * the patient show gout attack on taking allopurinol * the patient who have gastro-intestinal disease ( ex, crohn's disease, acute or chronic pancreatitis, ulcer )or who have the surgical history of gastrointestine. * the patient who should take azathioprine, mercaptopurine, cyclophosphamide, Losartan, benzbromarone,fenofibrate,furosemide ,probenecid * the patient who had taken part in the other study within 3months * the patient who had gotten blood transfusion * pregnant, breast feeding