A Non-inferiority, Multicenter and Randomized, Multiple-Dose Study About a Treatment to Hypolactasia

Inclusion Criteria: * To have participated in the single-dose clinical study (EF099) previously performed, with the clinical response being considered as satisfactory by the investigator * The patient should be a male or female, aged between 18 and 60 years old * Have a medical history consistent with lactose intolerance, confirmed by the test of hydrogen in the expired air * The female patients should agree to use birth control methods during the study participation * To be able to meet the study instructions and all the visits required * To give a free consent to participate in the study and sign the informed consent form (ICF). Exclusion Criteria: * Smoking * Secondary hypolactasia * Gastrointestinal inflammatories diseases - present diverticular disease, diabetic gastropathy or neoplasias * Colonoscopy or colon cleaning procedure 4 weeks before the start of study * Latrogenic: unnoticed intake of laxatives in over-the-counter drugs or alternative medicine, intake of cereal bran or probiotics * Diagnosis of HIV, immunodepression of any origin, or cancer under treatment. * Diagnosis of other comorbidity that, at the investigator's discretion, may compromise the study participation (e.g., systemic infection during the study or use of antibiotics in the last 4 weeks, diabetes mellitus, uncontrolled hypertension or renal failure), * Hypersensitivity or previous laboratory or clinical adverse event related to the use of lactase or any of the components of the formulations used in the study * Incapacity to understand and complete the study questionnaires, including the questions that require the use of the Visual Analogue Scale and ICF * Pregnancy or lactation * Use of alcohol, exceeding 3 doses daily * Participation in another clinical study on the last 12 months * Patient having some chronic pulmonary disease that, in the investigator's opinion, may harm or interfere with the expired hydrogen test (e.g., cystic fibrosis).