Efficacity, Safety and Cost of Intravenous Morphine Titration Alone or Combined to Ketamine

Assistance Publique - Hôpitaux de Paris160 enrolled

Overview

This is a randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine.

Randomised, controlled, double blinded study comparing in the postoperative setting the analgesic efficacy, the safety and the cost in two groups of patients receiving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

160

Conditions

Postoperative Pain

Interventions

KetamineDRUG

intravenous morphine titration combined to ketamine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 yrs * scheduled surgery * General anesthesia * ASA I to III * Able to use a VAS * No psychological disorders, able to speak french Exclusion Criteria: * Age \< 18 yrs * Locoregional anesthesia or analgesia * Allergia to morphine or ketamine * Morphine or ketamine contraindication * Pregnancy or breast-feeding

Locations (1)

Hopital Louis Mourier

Colombes, France

Outcomes

Primary Outcomes

analgesic efficacy

the analgesic efficacy, in two groups of patients recevieving in the postanesthesia care unit either intravenous morphine titration alone or intravenous morphine titration combined to ketamine

Time frame: 24 h

Data from ClinicalTrials.gov

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