1. To investigate whether the auditory stimulation causes changes in hormones levels (cortisol+prolactin) during general anesthesia. 2. To determine if there is a correlation between hormones levels (cortisol+prolactin) and dreams recall. 3. To investigate whether, in patients receiving auditory stimulation, there is a correlation between hormones levels (cortisol+prolactin), serum remifentanil concentration and detection of implicit memory. 4. To investigate the presence of primary auditory cortex activation (temporal lobe) in patients with implicit memory and in those with dreams recall using the EEG-ERP 128 channels GES300 EGI system.
Patients from group A, during maintenance of anesthesia, at the time of trocar insertion, will listen (via MP3) a piece of one of two stories, "Puss in Boots" and "Pinocchio", each followed by four keywords. In group B, patients will be isolated from the sounds of the operating room using specific headphones.
Study Type
OBSERVATIONAL
Enrollment
110
Catholic University of Sacred Heart
Rome, Italy
RECRUITINGHormones levels
The blood sample will be taken during anaesthesia to determine intraoperative hormones (cortisol + prolactine) levels.
Time frame: 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg
Hormones levels
The blood sample will be taken 30 minutes before induction of anaesthesia to determine baseline hormones (cortisol + prolactine) levels.
Time frame: Baseline
Remifentanil concentration
One blood sample will be taken to determine steady state concentration of remifentanil (only in a subset of patients).
Time frame: 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg
Memory
Patients will be asked to associate with keywords the first thing that comes them to mind (implicit memory). Also eplicit memory and dreams recall will be tested at the same time. The content of intraoperative dreams (confirmed by a brief post-anesthesia interview) will be analyzed using the 5-point Likert scale.
Time frame: Approximately 24 hours after surgery for explicit memory, implicit memory and for dreams recall detected after awakening from anesthesia
Primary auditory cortex activation
ERP-EEG monitoring system with 128 channel EGI GES300
Time frame: 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg
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