ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution

Inclusion Criteria: * Adult patients (between 18 and 75 years) affiliated with an appropriate social security system, diagnosed as suffering from symptomatic ORN, radiologically confirmed, for which surgery is indicated * Presence maximum of 2 outbreaks of ORN * Oncological remission of the original tumor site for 1 year and for 3 years if the ORN is in the contact or close to the initial tumoral site * ECOG performance status 0, 1 or 2 * ORN symptomatic accessible to the conservation of at least one cortical mandibular basilar * Signed informed consent Exclusion Criteria: * Oncological treatment * Haematologic background * Current bone necrosis consecutive or concurrent to taking bisphosphonates * Extension of ORN does not allow the retention of a mandibular rod (bicortical form) * Presence of fracture complicating ORN * Bisphosphonates during the last year * Contraindications to the removal of iliac or sternum bone marrow * Contraindication for general anesthesia