R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL

Inclusion Criteria: 1. Patients with untreated DLBCL aged 66 to 80 years without major accompanying diseases and considered as "non frail". 2. Patients were classified as "non frail" (fit) if they had * ADL (Activity of Daily Living) score of 6 * less than three grade 3 Cumulative Illness Rating Score for Geriatrics (CIRS-G) co-morbidities and no grade 4 co-morbidities * absence of geriatric syndrome 3. Patients HIV negativity; 4. Concurrent malignancy; 5. Written Informed Consent. Exclusion Criteria: * All other patients were classified as "unfit", and were excluded from randomization