The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak. Indead there are only few prospective studies which addressed this question without clear answer. Therefore we designed a RCT in order to assess the effect on mortality of two levels of mean arterial pressure in patients with septic shock.(800 patients, 30 centres)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
800
protocolized hemodynamic care aiming to maintain mean arterial pressure between 80-85 mm Hg
protocolized hemodynamic care aiming to maintain mean arterial pressure between 65-70 mm Hg
University hospital Angers
Angers, France
mortality
Time frame: day 28
decrease in mortality at day 90
Time frame: day 90
decrease in sequential organ failure assessment
Time frame: day 1 to day 28
extra renal replacement free days
Time frame: day 28
renal function
Time frame: day 1 to day 28
amount of fluids
Time frame: day 1 to end of shock
catecholamines free days
Time frame: day 1 to day 28
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