Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn

Ankara University70 enrolled

Overview

In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Wet Lung

Eligibility

Sex: ALLMin age: 34 WeeksMax age: 40 WeeksHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Gestation age \> 34 weeks * C/S delivered infants * Parental consent form signed Exclusion Criteria: * Gestation age \< 34 weeks * Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis) * Intrauterine growth retardation * Congenital malformations * Absence of parental consent

Outcomes

Primary Outcomes

Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.

At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.

Time frame: postnatal first 24 hours

Data from ClinicalTrials.gov

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