The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.
Study Type
OBSERVATIONAL
Enrollment
90
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting
Hye Jin Yoo
Seoul, South Korea
Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET
Time frame: 12 weeks
Circulating serum A-FABP levels
Time frame: 12 weeks
Circulating serum leptin levels
Time frame: 12weeks
Circulating serum adiponectin levels
Time frame: 12 weeks
Carotid intima-media thickness levels measured using ultrasonography
Time frame: 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.