Aim: to determine the effects of DHA supplementation: * on the platelet function through their aggregation and the pathway of arachidonic acid metabolism * on redox status on cells and plasma * on inflammation in 16 type 2 diabetic patients in a cross-over study comparing DHA (400 mg/day for 2 weeks) vs Sunflower oil (placebo). Each period is separated by a wash-out period of 6 to 9 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
16
400 mg DHA supplementation by day for 2 weeks during the first study period
400 mg DHA supplementation by day for 2 weeks during the second study period
Hospices Civils de Lyon
Bron, France
Centre de Recherche en Nutrition Humaine (CRNH) Rhône-Alpes
Pierre-Bénite, France
Platelet function induced by collagen
4 blood sampling are made during the time of study which expand from 10 weeks (washout period of 6 weeks) to 13 weeks (washout period of 9 weeks): * first at the beginning of the first period * second at the end of the period (2 weeks after beginning) * third at the beginning of the second period * fourth at the end of the period (2 weeks after beginning)
Time frame: 4 blood sampling in 10 to 13 weeks
Evaluation of cellular and plasmatic redox status
blood sampling are made during the time of study which expand from 10 weeks (washout period of 6 weeks) to 13 weeks (washout period of 9 weeks): first at the beginning of the first period second at the end of the period (2 weeks after beginning) third at the beginning of the second period fourth at the end of the period (2 weeks after beginning)
Time frame: 4 blood sampling in 10 to 13 weeks
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