Microaspiration in Pulmonary Fibrosis

University of California, San Francisco20 enrolled

Overview

Hypothesis 1: Microaspiration, as diagnosed by bronchoalveolar lavage (BAL) pepsin, is common in patients with IPF. Hypothesis 2a: Baseline clinical variables and co-morbid conditions are risk factors for microaspiration in patients with IPF. Hypothesis 2b: Baseline biological variables reflecting alveolar epithelial injury and inflammation are markers of microaspiration in IPF. Hypothesis 3a: Microaspiration will lead to a more rapid rate of decline in pulmonary function. Hypothesis 3b: Microaspiration will lead to higher rates of urgent medical care use (i.e. unscheduled clinic visit, emergency room visit, or hospitalization).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Idiopathic Pulmonary Fibrosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of IPF * Ability ot provide informed consent Exclusion Criteria: * History of fundoplication or other gastroesophageal surgery * Too ill to undergo bronchoscopy in the opinion of the investigator

Locations (1)

University of California San Francisco

San Francisco, California, United States

Outcomes

Primary Outcomes

BAL pepsin level

Time frame: Cross sectional

Data from ClinicalTrials.gov

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