Potential Beneficial Effects of Resveratrol

University of Aarhus24 enrolled

Overview

We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.

The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Metabolic Syndrome Obesity

Interventions

ResveratrolDIETARY_SUPPLEMENT

500 mg three times a day for five weeks.

PlaceboOTHER

Placebo (starch capsules) 500 mg three times a day for five weeks.

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \> 30 kg/m2 * Otherwise healthy * Written informed consent Exclusion Criteria: * Any disease * Alcohol dependency * Allergy to trial medication * Present or previous malignancy * Participation in other clinical trials within three months before randomization

Locations (1)

Aarhus University Hospital, Department of Endocrinology, MEA

Aarhus, Denmark

Outcomes

Primary Outcomes

Metabolic parameters

Regarding glucose, protein and fat metabolism.

Time frame: Five weeks

Secondary Outcomes

Pathways of substrate metabolism.

Description of the biochemical pathways underpinning the interplay between calorie restriction, SIRT1, STAT5 and the GH/IGF-I axis.

Time frame: Five weeks

Data from ClinicalTrials.gov

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