Carcinoma of the esophagus is the among the most common cancers in Indian population. While adenocarcinoma is more common in western countries, in India squamous cell carcinoma is the more frequent form. Surgery is the standard treatment in resectable lesions, but survival is poor. Adjuvant and neoadjuvant treatment therapy is used with an aim to improve the results. Though few randomized trials have addressed the issue of neoadjuvant chemoradiotherapy, the methodology was inhomogeneous and the populations studied were different. The investigators will be conducting a randomized controlled trial in patients with squamous cell carcinoma of the esophagus. Preoperative chemoradiation followed by surgery will be compared with surgery alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Patient with squamous cell carcinoma of esophagus will be treated with surgery alone
Patient with squamous cell carcinoma of esophagus will be treated by neoadjuvant chemoradiation followed by surgery
All India Institute of Medical Sciences
New Delhi, National Capital Territory of Delhi, India
RECRUITINGResectability rate
To compare the resectability rate of carcinoma esophagus between patients randomized to surgery alone and neoadjuvant chemoradiation followed by surgery
Time frame: 2 years
postoperative morbidity
To compare the postoperative morbidity between patients of carcinoma esophagus randomized to surgery alone versus chemoradiation followed by surgery
Time frame: 2 Years
operative mortality
To compare the operative mortality between patients randomized to surgery alone and neoadjuvant chemoradiation followed by surgery.
Time frame: 2 Years
Early disease control
To compare the early disease control in patients randomized to receive either neoadjuvant chemoradiation and surgery or surgery alone.
Time frame: 2 years
Treatment toxicity
This study will also assess the treatment toxicity of preoperative chemoradiation
Time frame: 2 years
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