A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients

Severance Hospital50 enrolled

Overview

Tracheal extubation can be associated with hyperdynamic circulatory response. The investigators examined the effect of maintaining a remifentanil infusion on the cardiovascular response during extubation in propofol-remifentanil sedated patients after surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Tracheal Extubation

Interventions

RemifentanilDRUG

Control group : stopping of propofol and remifentanil infusion Remifentanil group : stopping of propofol and maintenance of remifentanil infusion

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥ 20 2. Short term ventilator care after surgery in intensive care unit Exclusion Criteria: 1. pneumonia 2. chronic obstructive lung disease 3. asthma 4. end stage renal disease 5. risk factors for aspiration

Locations (1)

Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

Mean Arterial Pressure Changes During Extubation

Time frame: 10 min

HR Changes During Extubation

Time frame: 10 min

The Grade of Coughing During Extubation

Grade of cough was assessed on a four-point scale (0=no coughing, 1=single cough, 2=more than one episode of nonsustained coughing, 3=sustained and repetitive coughing with head lift).

Time frame: 2 min

Secondary Outcomes

Time of Awake

Time of BIS \> 80 : time between 'stopping of propofol'

Time frame: 1 hour

Time of Extubation

Time of extubation : time between 'stopping of propofol' and 'extubation'

Time frame: 1 hr

Data from ClinicalTrials.gov

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