A Study of RO5024048 in Japanese and Caucasian Healthy Volunteers

Inclusion Criteria: * Healthy male and female adults, 20 to 55 years of age, inclusive * Body mass index (BMI) 18 - 30 kg/m2 inclusive * Non-smoker, or previous smoker who discontinued smoking \>/= 6 month prior to study entry * Japanese subjects must be first generation: born in Japan, not having lived outside Japan \>5 years, able to trace maternal and paternal Japanese ancestry * Female subjects of childbearing potential and male subjects and their partners of childbearing potential must agree to use two forms of contraception * Agree to abstain from alcohol consumption and from strenuous exercise up to 3 days before dosing and throughout study (including the follow-up visit) Exclusion Criteria: * Positive pregnancy test * Males whose female partner is pregnant or trying to become pregnant * Positive urine test for drugs of abuse * Positive for alcohol * Positive result on hepatitis B, hepatitis C, or HIV test * Clinically significant disease or abnormalities in laboratory parameters * Participation in an investigational drug, biologic or device study within 3 months before study drug administration * Donation or loss of any blood over 450 mL within 3 months before study drug administration