Mechanisms of Stroke in Intracranial Stenosis

Jose Romano, MD100 enrolled

Overview

The objective of this SAMMPRIS-affiliated study is to understand the mechanisms the mechanisms that underlie ischemic stroke recurrence in high-grade intracranial atherosclerotic disease in order to determine predictors of recurrent stroke. MoSIS will evaluate 6 specific mechanisms of stroke in the medically-treated SAMMPRIS cohort: decreased antegrade flow, progression of stenosis, decreased proximal collateral flow, decreased distal collateral flow, impaired cerebrovascular reserve, and artery-to-artery embolism.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Stroke

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Enrolled in the medical arm of SAMMPRIS, signed consent Exclusion Criteria: * For QMRA testing: contraindications to MRI; for TCD testing, abscence of ultrasonographic windows.

Locations (1)

University of Miami

Miami, Florida, United States

Outcomes

Primary Outcomes

Ischemic stroke in the territory of the stenotic artery

Time frame: 2 years from enrollment

Data from ClinicalTrials.gov

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