Repetitive transcranial magnetic stimulation has been shown to be moderately effective in the treatment of major depression. Theta burst stimulation (TBS) is a new form of rTMS that may exert larger effects. This sham-controlled study examines the effectivity of daily bilateral TBS to the dorsolateral frontal cortex over 6 weeks in 2x16 patients with major depression add on to the local standard of a combined pharmacological/psychotherapeutical treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
32
intermittent TBS (iTBS) to the left DLPFC (600 stimuli, 80% resting motor threshold) continuous TBS (cTBS) to the right DLPFC (600 stimuli, 80% resting motor threshold)
University of Tübingen, Department of Psychiatry and Psychotherapy
Tübingen, Germany
Number of responders (response = decrease of the Montgomery-Åsberg Depression Rating Scale for at least 50%)
Time frame: after the end of treatment (week 6)
Change of the Hamilton rating scale for depression (HAMD 17)
Time frame: baseline, after the end of treatment (week 6)
Change of the Beck Depression Inventory (BDI)
Time frame: baseline, after the end of treatment (week 6)
Change of the Montgomery-Asberg rating scale for depression (MADRS) score
Time frame: baseline, after the end of treatment (week 6)
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