Colposeptine for the Treatment of Bacterial Vaginosis

Inclusion Criteria: * Female subjects in reproductive age and older than 18 year * Subjects with normal sexual activity * Subjects with symptoms such as vulva-vaginal irritation or abnormal vaginal discharge * Subjects with Nugent Score greater than or equal to 7 * Subjects who are willing to use contraception * Subjects who are willing to refrain from the use of other vaginal products throughout the study * Subjects who sign informed consent form and agree to follow-up on time Exclusion Criteria: * Subjects without sexual activity * Pregnant or lactating female subjects * Subjects with a history of recurrent bacterial vaginosis * Subjects diagnosed with trichomonas vaginitis，vulvovaginal candidiasis，chlamydia or gonococcus infection. * Subjects who are unwilling to refrain from the ingestion of any alcoholic beverages during the 7 day course of oral metronidazole therapy * Subjects who are under treatment by lithium, phenobarbitone, coumadine anticoagulant, cyclosporine or disulfiram by the time of inclusion (interactions with other products and metronidazole) * Subjects who are undergoing systemic or topical treatment with antibiotics, steroids, immunosuppressive, cytostatic or antimetabolic agents by the time of inclusion * Female subjects with a history of peripheral neuropathy * Female subjects who have participated in another clinical trial or have taken an experimental drug within the past 30 days * Subjects who are unable to give written informed consent