Study to Evaluate the Safety of the Vaccine Prepared sm14 Against Schistosomiasis

Inclusion Criteria: * Aged between 18 and 49 years. * Available for follow-up throughout the study period (approximately 120 days). * Ability to understand and sign the informed consent form (IC). * HIV serology negative * Absence of helminth infections in general (nematodes, cestodes and trematodes, among which Schistosoma mansoni) at the inclusion in the study. * Patients who has not chronic use or have not used in the past 45 days any medication, except trifling as nasal saline and vitamins. * Be in good health without significant medical history. * Screening physical examination without clinical significant abnormalities. * Screening laboratory tests without significant abnormalities according to normal standards and the evaluation of investigators. * Additional criteria for females of childbearing potential: Negative pregnancy test at screening; consistent use of contraceptive methods (male or female condom, diaphragm, IUD and oral contraceptives or "patches"). Exclusion Criteria: * Women who are pregnant or breastfeeding. * Use of cytotoxic or immunosuppressive drugs in the last six months, except for spray nasal corticosteroids for allergic rhinitis or topical corticosteroids for uncomplicated dermatitis. * Immunoglobulin use 60 days prior to vaccination. * Use of any type of vaccine 30 days prior to vaccination. * Plan to receive any other vaccine during the period of participation in the study (four months) * Use any type of investigational medication in a period of 30 days prior to vaccination * Use of allergy shots with antigens within 14 days prior to vaccination. * Psychiatric illness that hinders adherence to the protocol, such as psychosis, obsessive-compulsive neurosis, bipolar disorder treatment, diseases that require treatment with lithium, and suicide thoughts in the last 5 years prior to inclusion. * Presence of neurological disease, liver disease or kidney disease (diseases which have led to hospitalization or prolonged treatment). * History of sickle cell anemia. * Asplenia (no spleen or its removal). * History of alcohol use/abuse (CAGE criterion) or illicit drugs. * Blood pressure above 140/90 mmHg at screening or hypertension requiring drug treatment. * Coagulopathy diagnosed by a doctor or report of capillary fragility (eg, bruising, bleeding, etc.) after injections or blood sampling. * Active malignancy (eg, any type of cancer) or treated so it may relapse during the study. * History of allergy to vaccines containing adjuvants composed of lipids (GLA or MPL)