Study to Evaluate Darapladib in Moderately Hepatically Impaired Subjects

Inclusion Criteria: * A male or female is eligible to enter and participate in this study if he/she is a healthy subject OR a moderately hepatically impaired subject with a Child-Pugh score of 7-9. * Age between 18 and 65 years inclusive, at the time of signing the informed consent. * Body mass index (BMI) within the range of 19-37kg/m2 * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * QTcB \< 480 msec in all subjects, including those with bundle branch block at screening ECG * Healthy subjects only: AST, ALT, alkaline phosphatase and bilirubin less than or equal to 1.5xULN (isolated bilirubin greater than 1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin less than 35%) Exclusion Criteria: * Hepatically Impaired Group: * A positive pre-study drug/alcohol screen, except where subject has prescription for pain or anxiolytic medication that would cause positive test. * Subjects using any concurrent prohibited medication, and/or receiving concurrent therapy that cannot be safely discontinued and is not approved by the investigator * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer) * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Consumption of grapefruit or grapefruit juice \> 8oz within 7 days prior to first dose of study medication. * Currently receiving oral or injectable strong CYP3A4 inhibitor(s) * Subjects with any predisposing condition including malabsorption syndromes that might interfere with the absorption, distribution, metabolism, or excretion of drugs (except for hepatic impairment) or any previous gastrointestinal (GI) surgery (except appendectomy or gall bladder removal more than three months prior to the study). * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or medical monitor, contraindicates their participation. * History of anaphylaxis, or anaphylactoid (resembling anaphylaxis) reactions, or severe allergic responses. * Subjects with fluctuating or rapidly deteriorating hepatic function. Subjects should be medically stable in the opinion of the principal investigator, evidenced by liver function tests as well as clinical signs and symptoms for 30 days before the study. * Subjects with advanced ascites (Grade 3) or subjects with moderate or severe encephalopathy (Grade 3 or 4) as judged by the investigator. * History of sensitivity to heparin or heparin-induced thrombocytopenia (if heparin is to be used for flushing a cannula). * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Use of oral, injected and implanted hormonal methods of contraception for female subjects. * Pregnant females as determined by positive serum hCG test at screening or prior to dosing. * Lactating females. * Subjects with a positive HIV antibody test. * Subjects with creatinine clearance less than or equal to 60 mL/min (calculated by the Cockcroft-Gault Formula) * Subjects who, within the past two months, have had a history of drug or alcohol abuse or any indication of regular use of more than two units per day * Subjects with signs of active infection with constitutional symptoms. * Subjects with esophageal variceal bleeding, unless if banded and stable, within the past 6 months. * Subjects with a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to the study drug. * Subjects with any history of heart failure. * Subjects with unstable coronary heart disease (unstable angina, acute coronary syndrome, or unstable cardiac rhythm) within the past 6 months. * Subjects with any other medical condition which, in the judgement of the investigator and medical monitor, could jeopardize safety or welfare of the subject and/or the integrity of the data derived from that subject. * Severe asthma that is poorly controlled on pharmacotherapy * Subjects with a risk of non-compliance in following directions or adhering to study restrictions or any subject that the principal investigator deems unsuitable for continuation in study conduct. * Healthy Volunteer matched group: * A positive pre-study drug/alcohol screen. * A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody or positive Hepatitis A IGM antibody result within 3 months of screening * A positive test for HIV antibody. * History of regular alcohol consumption within 6 months of the study * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, or 5 half-lives of the investigational product (whichever is longer). * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St. John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and medical monitor the medication will not interfere with the study procedures or compromise subject safety. * Currently receiving oral or injectable strong CYP3A4 inhibitor(s) * Consumption of grapefruit or grapefruit juice \> 8oz within 7 days prior to first dose of study medication. * Alcohol or drug abuse within the past 6 months, or current mental condition (psychiatric disorder, senility or dementia), which may affect study compliance or prevent understanding of the aims, investigational procedures or possible consequences of the study * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or medical monitor, contraindicates their participation. * History of anaphylaxis, or anaphylactoid (resembling anaphylaxis) reactions, or severe allergic responses. * Severe asthma that is poorly controlled on pharmacotherapy * History of cholecystectomy or biliary tract disease, or a history of liver disease with elevated liver function tests of known or unknown etiology. * History of sensitivity to heparin or heparin-induced thrombocytopenia (if heparin is to be used for flushing a cannula). * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Use of oral, injected and implanted hormonal methods of contraception for female subjects. * Pregnant females as determined by positive serum hCG test at screening or prior to dosing. * Lactating females. * Unwillingness or inability to follow the procedures outlined in the protocol. * Subject is mentally or legally incapacitated.