Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement11 enrolled

Overview

Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Enrollment

Conditions

Pancreatitis

Interventions

CreonDRUG

No enzyme therapyOTHER

Current enzyme therapy of the patient is stopped during 7 days

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic pancreatitis * Pancreatic insufficiency * Enzyme therapy treatment Exclusion Criteria: * Hepatic failure * Pregnancy * Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease

Locations (1)

Centre de Recherche sur Volontaires

Bobigny, France

Outcomes

Primary Outcomes

transfer of dietary nitrogen to metabolic pools

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.