Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine

McGill University Health Centre/Research Institute of the McGill University Health Centre60 enrolled

Overview

Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result of a significant opioid sparing and attenuated inflammatory response.

The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early postoperative physical activity recovery of patients scheduled for laparoscopic colorectal resection. The study focuses on patients with colorectal disease, which receive the laparoscopic (assisted) surgical approach. It is hypothesized that in those patients receiving perioperative and post-operative intravenous lidocaine, bowel function recovery will be faster, probably as a result of a significant opioid sparing, less pain and attenuated inflammatory response.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Colon Cancer Inflammatory Bowel Diseases Diverticulitis

Interventions

LidocaineDRUG

1% Lidocaine 1mg/kg/hr IV drip x 48hr

Thoracic epidural blockPROCEDURE

0.1% Epidural bupivacaine + Morphine 0.02 mg/ml drip via epidural x48 hr

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * scheduled to undergo laparoscopic colorectal resection Exclusion Criteria: * patients who have trouble to understand, read or communicate either in French or in English * dementia * patients suffering from severe physical disability (arthritis, neuromuscular dysfunction, stroke, paraplegia) or inability to walk or conduct daily activity * patients suffering from severe cardiac or respiratory disease (status ASA IV * patients suffering from metastatic carcinoma * patients who have a history of chemoradiation within the six months preceding surgery * allergy to lidocaine * morbid obesity * patients with chronic opioid use.

Locations (1)

MUHC

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Restoration of bowel function

Time frame: 72 hours after an operation

Secondary Outcomes

Pain intensity

Visual analog score pain (from 0-10) at rest, on walking and coughing at 24, 48 and 72 hours after an operation are assessed.

Time frame: within 72 hours after an operation

Data from ClinicalTrials.gov

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