The purpose of this study is to evaluate whether beta-blocker therapy improves 6-year clinical outcomes in patients with ST-segment elevation acute myocardial infarction and preserved left ventricular ejection fraction after primary percutaneous coronary intervention.
Beta-blocker therapy is recommended after ST-segment elevation acute myocardial infarction (STEMI) in the current guidelines although its efficacy in those patients who have undergone primary percutaneous coronary intervention (PCI) has not been adequately evaluated. The purpose of this study is to evaluate whether beta-blocker, carvedilol improves 6-year clinical outcomes in patients with STEMI and preserved left ventricular ejection fraction after primary PCI. The design of this study is multicenter, open-label, randomized controlled trial enrolling 1300 patients without any exclusion criteria.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
801
Use of Carvedilol with any dose
No use of Carvedilol
Division of Cardiology, Kyoto University Hospital
Kyoto, Japan
All cause mortality
Death from any reason
Time frame: 6-year
Composite of death, myocardial infarction, acute coronary syndrome, heart failure hospitalization
Time frame: 6-year
Cardiac death
Time frame: 6-year
Sudden cardiac death
Time frame: 6-year
Cardiovascular death
Time frame: 6-year
Myocardial infarction
Time frame: 6-year
Acute coronary syndrome
Time frame: 6-year
Sustained ventricular tachycardia or ventricular fibrillation
Time frame: 6-year
Heart failure hospitalization
Time frame: 6-year
Stent thrombosis
Stent thrombosis defined by Academic Research Consortium
Time frame: 6-year
Target-vessel revascularization
Time frame: 6-year
Clinically-driven target-lesion revascularization
Time frame: 6-year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Any coronary revascularization
Time frame: 6-year
Any clinically-driven coronary revascularization
Time frame: 6-year
Coronary artery bypass grafting
Time frame: 6-year
Stroke
Any ischemic and hemorrhagic strokes excluding transient ischemic attacks
Time frame: 6-year
Worsening of angina due to coronary spasm
Time frame: 6-year
Bleeding complications
Bleeding complications defined by GUSTO and TIMI definitions
Time frame: 6-year
Composite of death, myocardial infarction, stroke, acute coronary syndrome, heart failure hospitalization, any coronary revascularization
Time frame: 6-year
Composite of cardiac death, myocardial infarction, acute coronary syndrome, heart failure hospitalization
Time frame: 6-year
Composite of cardiovascular death, myocardial infarction, stroke
Time frame: 6-year