Procalcitonin as a Marker for the Length of Antibiotic Treatment in Peritonitis and Intra-abdominal Infections

University of Lausanne Hospitals162 enrolled

Overview

Procalcitonin level used for determining length of antibiotic treatment in peritonitis and intra-abdominal infections. Hypothesis is that length of antibiotic use can be shortened by this method.

Prospective randomized trial

Study Type

OBSERVATIONAL

Enrollment

162

Conditions

Secondary or Tertiary Peritonitis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * More than 18 yo * Patient requiring surgery for peritonitis or intra-abdominal infection following: perforation, necrosis, previous operation... * Mannheim Peritonitis score \> 14 * SIRS present * Probability of survival \> 72h * Informed consent by patient/relatives Exclusion Criteria: * No SIRS * Long date corticoid treatment * Immunosuppression * Thyroid medullary carcinoma * Anaphylactic shock * Acute hepatic deficiency

Locations (1)

University Hospital of Lausanne

Lausanne, Switzerland

Outcomes

Primary Outcomes

antibiotic treatment length, hospitalisation length without antibiotic, infection recurrence, antibiotic cost

Time frame: at one month and during hospital stay

Data from ClinicalTrials.gov

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