Confocal laser endomicroscopy (CLE) is a newly endoscopic device that enables microscopic view of the digestive tract. The purpose of this study is to determine if confocal laser endomicroscopy can improve detection of digestive disease include inflammation, dysplasia, and early cancer, and if confocal laser endomicroscopy has competitive advantage, compared with other device such as Narrow Band Imaging and Autofluoresecence Imaging.
Advances in endoscopy have led to imagining of the details of digestive mucosa. Novel techniques such as Narrow Band Imaging (NBI) assisted magnification endoscopy, Auto Fluorescence Imaging (AFI) or confocal laser endomicroscopy could, however, improve the endoscopic detection.In this research we describe the combined use of these three techniques in patients with digestive disease.
Study Type
OBSERVATIONAL
Enrollment
500
Confocal laser endomicroscopy is performed using the Pentax/Optiscan confocal endomicroscopy and 5 ml of 10% intravenous fluorescein sodium. Photos of magnified images of the digestive mucosa are taken during the procedure.
NBI/AFI endoscope offers an alternative light source involve NBI and AFI to view digestive mucosa in real time.
China PLA General Hospital
Beijing, Bejing, China
RECRUITINGDiagnostic yield for neoplasia of CLE vs. standard endoscopy
Time frame: one year
Diagnostic yield for neoplasia of CLE vs. NBI/AFI
Time frame: one year
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