Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis

Inclusion Criteria: * Aged 18 and older eligible to sign by themselves. * Have a clinical diagnosis of Acute Otitis Externa based on clinical observation and of presumed bacterial origin. * Intact tympanic membrane * Unilateral Acute Otitis Externa Exclusion Criteria: * Known allergy or sensitivity to Ciprofloxacin or other quinolones. * Clinical Diagnosis of chronic suppurative otitis media (CSOM), acute otitis media (AOM), involvement of middle ear effusion (MEE). * Patient has the non intact tympanic membrane. * Patient has a serious underlying disease. * Patients with known history of immune dysfunction/deficiency and those receiving immunosuppressive therapy. * Patients with history of Diabetes mellitus. * Bilateral Acute Otitis Externa. * Patients with more than 80% of the ear canal occluded. * Pregnant or lactating patients. * Overt fungal Acute Otitis Externa. * Local ear canal abnormalities such as abscess, granulation or polyps. * Congenital abnormalities of the external auditory canal or obstructive bony exostosis in the treated ear. * Mastoid or other suppurative non-infectious ear disorder (e.g. cholesteatoma) in the treated ear. * Seborrheic dermatitis or other dermatological conditions of the external auditory canal which would complicate evaluation. * Current Infection requiring systemic antimicrobial therapy. * Current or previous use of topical or oral antibiotics (within 3 days) or long-acting antibiotics (within 7 days). * Current enrollment in an investigational drug or device study or participation in such a study within 30 days of entry into this study.